Trehalose‐6‐phosphate‐mediated phenotypic change in Acinetobacter baumannii
JJ Hubloher, S Zeidler, P Lamosa… - Environmental …, 2020 - Wiley Online Library
The stress protectant trehalose is synthesized in Acinetobacter baumannii from UPD‐
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that
deletion of otsB led to a decreased virulence, the inability to grow at 45° C and a slight
reduction of growth at high salinities indicating that trehalose is the cause of these
phenotypes. We have questioned this conclusion by producing∆ otsA and∆ otsBA mutants
and studying their phenotypes. Only deletion of otsB, but not deletion of otsA or otsBA, led to …
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that
deletion of otsB led to a decreased virulence, the inability to grow at 45° C and a slight
reduction of growth at high salinities indicating that trehalose is the cause of these
phenotypes. We have questioned this conclusion by producing∆ otsA and∆ otsBA mutants
and studying their phenotypes. Only deletion of otsB, but not deletion of otsA or otsBA, led to …
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